Paleo Ketogenic Diet

Valter Longo, Ph.D. on Fasting-Mimicking Diet & Fasting for Longevity, Cancer & Multiple Sclerosis



Dr. Rhonda Patrick speaks with Dr. Valter Longo, a professor of gerontology and biological sciences and director of the longevity institute at the University of Southern California. Dr. Longo has made huge contributions to the field of aging, including the role of fasting and diet in longevity and healthspan in humans as well as metabolic fasting therapies for the treatment of human diseases.

In this conversation, Rhonda and Valter discuss…
• The effects of prolonged fasting, which refers to 2-3 day fasting intervals in mice and 4-5 days in humans.
• Dr. Longo’s work on the fasting-mimicking diet, which is 5 day restricted diet that is meant to simulate some of the biological effects of prolonged fasting while still allowing some food.
• How clinical trials have demonstrated efficacy for this diet for type 2 diabetes, multiple sclerosis, and cancer patients.
• Fasting as an inducer of differential stress resistance, where it can simultaneously make cancer cells more sensitive to death while also making healthy cells more resistant to these same death stimuli (such as chemotherapy) which might otherwise induce cell death amongst healthy cells as collateral damage.
• Fasting as a biological state which humans historically experienced with extreme regularity and we may ultimately need in order to mitigate various disease states.
• The effects of prolonged fasting on the immune system, namely, how it clears away damaged white blood cells via autophagy and how this causes hematopoietic stem cells to self renew and make more stem cells and also produce new blood cells to fully replenish the white blood cell population.
• How prolonged fasting causes a shift in the immune cell population towards one that is more representative of youth by normalizing the ratio of myeloid cells to lymphoid cells.
• The positive effects of prolonged fasting and the fasting-mimicking diet on markers of systemic inflammation, blood glucose levels and other aging biomarkers.
• The conclusions of Dr. Longo & Dr. Marcus Bock’s research comparing 1 week of the fasting-mimicking diet followed by 6 months of mediterranean diet to six months of a ketogenic diet in people with multiple sclerosis.
• The strange, somewhat paradoxical role of autophagy genes in cancer progression and some of the open questions surrounding the exact role that these genes are playing.
• Dr. Longo’s high level thoughts on metformin as an anti-aging drug.
• How the growth hormone/IGF-1 axis is one of the most important genetic pathways in aging from yeast to worms to mice to humans.

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46 comments

  1. Regarding how intermittent fasting puts the normal cells in the body in a strong defense position, thus leaving cancer cells more vulnerable and susceptible to chemo.. Dr. Mark Pientel of SIBO/IBS fame suggests this is also true for gut bacteria. If you're using Xifaxan/rifaximin to kill bacteria (the good and bad I suppose), the efficacy is greater in the presence of food ( "You gotta feed ’em to kill ’em.”).

    Would love to hear an episode strictly devoted to the pros/cons of supplementing with Metformin and Rapmycin. It would be interesting to hear exactly the areas that Dr. Valter Longo and Dr. Matt Kaeberlein agree and disagree on!

  2. I still hear so much fear about fasting.   I water fast for 84 to 106 hours and still workout and feel great….  my weight as a 6 foot male has fluctuated between 220 and 165 a few times as various life events have affected me.  Now at 55 I am fasting back down from 220 to 175 without cardio which damaged my knees 10 years ago and I find all the benefits of being rid of sugar cravings and improved mental focus and outlook as the most wonderful blessings FROM Fasting…  I have no fear of fasting 3 to 4 days as long as I still have 10 extra pounds and then juicing and going keto of even  eating vegan superfoods with enough calories and protein FOR SEVERAL DAYS and then fasting again.

  3. What about CD36 protein in case of prolong fasting. New study 07.12.2016 in Nature showed that this type (CD36) of protein is responsible for matastatis cancer, CD36 high corelations with fatty acids. How does that works with fasting ?
    “Targeting metastasis-initiating cells through the fatty acid receptor CD36″

  4. Excellent interview. And kudos to Dr. Longo for creating a company to help cancer patients and refusing to benefit financially from the sales. What an honorable man.

  5. It would be interesting to hear you address the Randle Effect. Overall, this seems very stressful on the body and being in a lipolytic state one step closer to primitive cancer metabolism. I don't see how piling on physiological stress makes sense in the context of health. Reverse Warburg Effect and autophagy are interesting new areas of discovery, but they do not cure cancer. I think fasting being normal is speculative. I don't know any species that thrives and proliferates during times of famine. It's just as easy to speculate that our cells and genome were cultivated over millions of years in environments of abundance.

  6. Fasting helps dramatically, but it is not the only way to shrink and condense tissues. CT (Cold Thermogenesis) works well. Water itself it most condensed at 4 degrees Celsius. Add specific wavelengths from the sun to the water, and you've got some awesome condensing. That's why we heat up when we're sick to help condense if we are damaged for those wavelengths. This will all become as clear as day if you guys look up Gerald Pollack's works on Exclusion Zone water and read or watch some videos from Doug Wallace on mt(DNA) heteroplasmy, you'll see how the mitochondria is profound here in ALL of these systems…cancer, MS, etc. More respiration potential when you shrink tissues for better energy to help mitigate the damage.

  7. Soup (fasting-mimicking) made of the most active anti-Cancer vegetables
    { 1 day serving = 2 bowls (@ 10am & 5pm – Water only past 6pm)}:
    1 cup water
    2 Tb (Flax oil) =                       240 cal
    2 Tb Ground flax seed =         90 cal
    1 cup Broccoli sprouts =            25 cal  
    1 cup Brussels sprouts =            50 cal
    1 Leek =                                      75 cal
    1 bulb garlic =                             50 cal
    1 cup parsley =                            25 cal
    1 cup white Mushrooms 15 cal
    1 Tb. turmeric =                         25 cal
    1 Tb. Paprika=                       25 cal
    1 Tb. Cardamon = 4 cal
    1/2 tsp. white pepper =                2 cal
    1 tsp. Oregano = 4 cal
    1 tsp Ginger powder= 4 cal
    1/4 tsp Cayenne Pepper 1 cal
    —————————————————————————————————–
    =  approx. 638 calories   (@ approx.44% fat)
    *Dependent upon weight & enough exercise exerted to burn the
    calories.

     To Prepare :Use fresh vegs only: First warm Sprouts, then mash/blend
    vegs.
    Prep See > https://www.youtube.com/watch?v=Z7buU-PK7_I&t=5s
    Best Vegs > https://www.youtube.com/watch?v=8tAAehC4BYs
    Flax see > https://www.youtube.com/watch?v=1XhN3gyCOzs
    Turmeric > https://www.youtube.com/watch?v=qPoKvSH9J_A
    Cardamon > https://www.youtube.com/watch?v=FGtS_h_xTuc
    Paprika > https://www.ncbi.nlm.nih.gov/pubmed/11566483
    Oregano > https://www.youtube.com/watch?v=IXEt_ZPPfjk
    Parsley >
    http://munews.missouri.edu/news-releases/2011/0509-parsley-celery-carry-crucial-component-for-fight-against-breast-cancer-mu-researcher-finds/
    Mushroom > mushroom https://www.youtube.com/watch?v=fX9mIzGcjDk

  8. I am on Xeloda and would like to try to do this FMD at the same time. Is there a clinical trial or a doctor that I could contact that could help me with this. I have just been diagnosed with Stage IV triple negative bc.

  9. I've been eating two meals, no snacking IF 18/6 for 16 days. I feel as sharp as a tack. I feel I could keep this going forever. I'll see how it goes and probably try other protocols as well. Whole Foods (nothing processed)

  10. It would also be interesting if there is further interviews/discussion regarding the FGF1 protein. "We report that a single intracerebroventricular injection of FGF1 at a dose one-tenth of that needed for antidiabetic efficacy following peripheral injection induces sustained diabetes remission in both mouse and rat models of T2D. This antidiabetic effect is not secondary to weight loss, does not increase the risk of hypoglycemia, and involves a novel and incompletely understood mechanism for increasing glucose clearance from the bloodstream. We conclude that the brain has an inherent potential to induce diabetes remission and that brain FGF receptors are potential pharmacological targets for achieving this goal."
    http://www.nature.com/nm/journal/v22/n7/full/nm.4101.html

    And this Salk Institute on FGF1 and Insulin Sensitivity in 2014
    https://www.youtube.com/watch?v=i7fF7EWER4s

  11. Moderate exercise is an essential component of a protocol.
    Melatonin at night – 7 hours of sleep .
    ————————————————————————————————————————–
    Supplements :
    Vitamin D & K2, CoQ10,  B12, MSM 
    ———————————————————————————–
    Medicianal Herbs:
    Dandelion Root , Amla berry,  Astragalus, Milk thistle, Chaparral, Juniper Berry, Yerba
    Mansa, Jiaogulan , Frankincense.
    ——————————————————————————————————————————–
    Personal Physician could be consulted concerning the following:
    Asprin    
    Cannabis
    Metformin
    Rapamycin – Reduces protein synthesis > http://www.selleckchem.com/products
    3 Bromo-pyrovate –> https://www.ncbi.nlm.nih.gov/pubmed/22382780/ Also > https://www.scbt.com/scbt/product/3-bromopyruvic-acid-1113-59-3
    ————————————————————————————————————————–
    Avastin >(Inhibits vein production)  http://www.avastin.com/patient/about/how-avastin-works/mcrc
    Keytruda (Melanoma)

  12. Hey, Dr. P! Nice hair, as everyone else has said. Looking hot hot!
    Thanks for the vidya, soooo much learned and sooo many more questions.
    It's incredibly interesting how Dr. Longo has reframed the idea of fasting as a more "natural" state. At about 49 minutes you talked about quiescent hematopoietic stem cells relying on the serum low-glucose/high-ketone environment to induce proliferation and stemness due to this environment and how this is a more bioenergetically favorable environment due a reduced need for oxygen. This perfectly fits Dr. Longo's view on the more "natural" state re: fasting. Further, it would fit the Nutritional Neurotrophic Neoteny theory, which I have only just become aware of.

    Anyway, good work, especially the explanations in the boxes and article displays. So educationally oriented due to its repetition.

  13. Here is one of many possible references on the value of training with low glycogen to maximize the stress response through p53 signaling. Valter's talk echoes the values of depleting muscle glycogen a supports a point I have been making for years on the value of training while hungry and not diminishing the adaptive response by consuming high glucose/high protein "gainer" drinks. Bartlett, J. D., Louhelainen, J., Iqbal, Z., Cochran, A. J., Gibala, M. J., Gregson, W., et al. (2013). Reduced carbohydrate availability enhances exercise-induced p53 signaling in human skeletal muscle: implications for mitochondrial biogenesis. American Journal of Physiology Regulatory, Integrative and Comparative Physiology, 304(6), R450–R458. http://doi.org/10.1152/ajpregu.00498.2012

  14. I've watched this several times. Intriguing discussion, as always. Would love to hear more about implications for athletes in weight category sports who need to drop weight without losing muscle mass. The one comment near the end of the video has sparked interest with several of my athletes.

  15. where can we find the protocols of all the diets? (fmd for longevity, for chemo, the 7 days one, etc.) will they be in the book or are we obliged to buy the packaged meals?

  16. Hey Rhonda,

    I just went out of my way to sign up as a crowdsponsor after a month of learning.
    I bet I'm not the only one.

    Such brilliant value in what your doing here.
    Thanks and keep going, you have your finger on the pulse, proud to be apart of it.

    P.S
    I've been working a 4hr eating window ( exercise just before refeed where possible ) and contrast showers for a few months now and it keeps me in great form.
    But no longer taking cold showers/sauna's right after lifting 😉

    Regards,
    Rob

  17. Why would fasting be the norm of the past? Humans were smart for thousands of years and were smart enough to store large amounts of food to deal with bad weather and seasons. And did Dr Longo do the studies using low fat diet? The Australian mice studies showed better mice longevity with low protein low fat high carbohydrate diet.

  18. Love Rhonda's work. But question, i have a fast metabolism, even eating constantly i need to eat lots to maintain my weight. Ive experimented with vegetarianism and always lose so much weight, muscle mass. I wonder if its possible to eat this way without looking like a shipwreck victim

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