Dr. Tom Sutula Interview
“What is 2DG and Does it Mimic the Ketogenic Diet?”
Recorded at The Charlie Foundation’s 5th Global Symposium for Ketogenic Therapies in Banff, Alberta, Canada
Thomas P. Sutula, MD, PhD, is a Professor and the Chairman of Neurology at the University of Wisconsin School of Medicine and Public Health. His medical interests focus on the basic mechanisms and clinical aspects of epilepsy.
The laboratory studies activity-dependent circuit plasticity in the developing and adult hippocampus, a region of brain that plays a role in learning, memory, and epilepsy. Previous studies from the laboratory have demonstrated that seizures (an intense form of neural activity) induce enhanced synaptic transmission, progressive neuronal death, and axon sprouting which are accompanied by permanent functional alterations in hippocampal circuits including increased susceptibility to additional seizures and memory dysfunction. In developing rats, seizures also modify formation of hippocampal circuits and induce long-term alterations in the capacity for hippocampal synaptic plasticity and learning. Acute and chronic electrophysiological, anatomical, and behavioral methods are being used to study how neural activity and seizures modify the hippocampal organization and function. A variety of molecular and genomic approaches are being used to study how long-term alterations in hippocampal circuits are produced by neural activity, and we are also examining how alterations in the extracellular ionic environment interacting with seizure-induced circuit reorganization in the dentate gyrus contribute to emergent properties such as recurrent excitation and network synchronization.